低分子量肝素由天然肝素分離或是降解得到。臨床用于預防手術(shù)后血栓栓塞、預防深靜脈血栓形成、肺栓塞、血液透析時(shí)體外循環(huán)的抗凝劑、末梢血管病變等。
低分子量肝素是低分子量肝素鈉鹽，通過(guò)從豬肉腸道粘液中分離肝素的硝基酸脫聚而獲得。作為一種新的抗血栓類(lèi)，低分子量肝素鈉在預防或治療劑量下施用時(shí)提供立即和持續的抗血栓活性。它用于預防血液透析期間凝血和預防深靜脈血栓（DVT）。浩然生物制藥可供應具有以下規格的散裝低分子量肝素鈉。各種規格的產(chǎn)品也可以根據客戶(hù)的要求進(jìn)行準備。
Dalteparin Sodium (Low Molecular Weight Heparin Sodium) (LMWH-Na) is the sodium salt of Low Molecular Weight Heparin obtained by nitrous acid depolymerization of heparin from pork intestinal mucosa.
As a new antithrombotic class, Dalteparin Sodium provides immediate and sustained antithrombotic activity when administered in prophylactic or therapeutic dosage. It is indicated for prevention of clotting during hemodialysis and prophylaxis of Deep Venous Thrombosis (DVT).
Haoran Biopharma can supply bulk Dalteparin Sodium with the following specifications. Products of various specifications can also be prepared according to customers' requests.
|
Appearance |
White or almost white powder |
|
Clarity of solution |
Clear |
|
Anti-factor Xa activity |
110AXa IU/mg ~ 210AXa IU/mg |
|
Anti-factor IIa activity |
35 AIIa IU/mg-100 AIIa IU/mg |
|
The ratio of anti-factor Xa to anti-factor IIa |
1.9 ~ 3.2 |
|
Sodium |
9.5% ~ 12.5% |
|
Range of molecular weight |
<3000: Not more than 13.0% >8000: 15.0% ~ 25.0% |
|
Mass-average molecular mass |
5600 ~ 6400 |
|
pH |
5.5 ~ 8.0 |
|
Nitrite |
Not more than 5ppm |
|
Nitrogen |
1.5% ~ 2.5% |
|
Heavy metals |
Not more than 30ppm |
|
Loss on drying |
Not more than 5.0% |
|
Nucleotide and protein impurities of the source material |
Pass |
|
Boron |
Not more than 1ppm |
|
Bacterial endotoxins |
Not more than 0.01IU/AXaIU |
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